Polyarteritis Nodosa (PAN)

Polyarteritis Nodosa (PAN) Polyarteritis Nodosa (PAN) Polyarteritis Nodosa (PAN)
Polyarteritis Nodosa (PAN)

Why Choose Niruj Clinic?

At Niruj Rheumatology & Allergy Clinic, we provide specialized care for Polyarteritis Nodosa (PAN) through early diagnosis, personalized treatment plans, and continuous expert monitoring to reduce complications, protect vital organs, and improve long-term quality of life.

What is Polyarteritis Nodosa?

Polyarteritis Nodosa (PAN) is a rare autoimmune vasculitis that causes inflammation of medium-sized arteries, reducing blood flow to vital organs such as the skin, nerves, kidneys, digestive system, and heart. At Niruj Rheumatology & Allergy Clinic, our experienced rheumatologists provide comprehensive evaluation, advanced investigations, and personalized treatment plans to ensure early diagnosis, effective disease control, and better long-term outcomes.

Treatment Options

  • glucocorticoids – Reduce inflammation and control disease activity.
  • Immunosuppressants (Methotrexate, Azathioprine) – Suppress the overactive immune system.
  • Cyclophosphamide – Used for severe or life-threatening cases.
  • Treat underlying Hepatitis B (if present) – Antiviral therapy is essential for HBV-associated PAN.
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Polyarteritis Nodosa

Common Symptoms

Disease at a Glance

Autoimmune Vasculitis

Autoimmune Vasculitis

Affects Medium-Sized Arteries

Affects Medium-Sized Arteries

ANCA-Negative Vasculitis

ANCA-Negative Vasculitis

Chronic, Relapsing Condition

Chronic, Relapsing Condition

Not Curable, But Controllable
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Not Curable, But Controllable

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Treatable & Controllable

What Happens in Polyarteritis Nodosa?

PAN-Affected Artery

  • Inflammation of the artery wall
  • Narrowing of medium-sized arteries
  • Reduced blood flow to organs
  • Aneurysm formation
  • Tissue / organ damage
VS

Healthy Artery

  • Smooth, elastic artery wall
  • Normal artery diameter
  • Adequate blood supply to organs
  • No aneurysm formation
  • Normal organ function

Who is at Risk?

Autoimmune predisposition
Hepatitis B infection
Adults of any age
Exact cause often unknown
Both men & women affected

Our Specialists

Our team of experienced specialists provides expert care tailored to your unique health needs.

Dr. Anuj Shukla
Dr. Anuj Shukla Head & Consultant Rheumatologist
Qualifications MBBS (NHL MMC), MD (General Medicine, MAMC)
Designation Consultant Rheumatologist
Dr. Kishan Majithiya
Dr. Kishan Majithiya Consultant Rheumatologist & Allergy Specialist
Qualifications MBBS, DNB (Internal Medicine), DM (Clinical Immunology & Rheumatology)
Designation Consultant Rheumatologist and Allergy specialist
Dr. Priyanka Gaur
Dr. Priyanka Gaur Clinical Immunology & Rheumatology
Qualifications BSC, MSC(Biotechnology), PHD(Clinical Immunology)
Designation Clinical Researcher
Dr. Nirav Makwana
Dr. Nirav Makwana Doctor
Qualifications B.H.M.S
Designation Medical Officer
Dr. Divya Nagar
Dr. Divya Nagar Medical Officer
Qualifications B.H.M.S
Designation Medical Officer

Why Patients Trust Niruj Rheumatology & Allergy Clinic

Compassionate, evidence-based rheumatology care focused on long-term wellness.

Evidence-Based Treatment

Internationally accepted protocols tailored to each patient’s condition.

usp background

10+ Years

Specialized Rheumatology Experience

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Compassionate & Long-Term Care

Dedicated management of autoimmune and joint disorders with continuous follow-up for sustained health improvement.

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Accurate & Early Diagnosis

Early detection prevents irreversible joint damage and long-term disability.

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Modern Diagnostic Support

Advanced lab investigations and imaging for precise assessment.
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Transparent Communication

Clear explanation of diagnosis, treatment options, and expected outcomes.

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Patients Managed

Diagnosis Process

Diagnosis includes blood tests, Hepatitis B testing, CT or MR angiography to detect aneurysms, and biopsy of skin, nerve, or muscle when needed.

Detailed Disease Assessment

Clinical Assessment

Medical history and physical examination to assess symptoms and organ involvement.

01
Blood Tests

Blood Tests

Blood tests and Hepatitis B screening to evaluate inflammation and associated conditions.

02
MRI Scan

CT or MR Angiography

CT or MR angiography is performed to detect aneurysms and assess inflammation in medium-sized arteries.

03
Biopsy

Biopsy Confirmation

A skin, nerve, or muscle biopsy may be recommended when needed to confirm the diagnosis.

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Our Approach to Personalized Rheumatology Care

Frequently Asked Questions (FAQs) – ANCA Vasculitis

What is Polyarteritis Nodosa (PAN)?
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Polyarteritis nodosa is a rare autoimmune disease that causes inflammation of medium-sized arteries, leading to reduced blood flow and damage to organs.
Is PAN ANCA positive?
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No, PAN is typically ANCA-negative, which helps differentiate it from other vasculitis types like ANCA-associated vasculitis.
What causes PAN?
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The exact cause is unknown, but:

  • It is an autoimmune condition
  • Some cases are associated with Hepatitis B infection
Which organs are affected in PAN?
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PAN can affect multiple organs, especially:

  • Kidneys → high blood pressure
  • Nerves → weakness, numbness
  • Skin → rash, ulcers
  • Gastrointestinal tract → abdominal pain
  • Heart → rare but serious involvement
What are the early symptoms of PAN?
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Early symptoms are often non-specific:

  • Fever
  • Fatigue
  • Weight loss
  • Muscle pain
What are specific symptoms of PAN?
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  • Livedo reticularis (net-like skin rash)
  • Skin nodules or ulcers
  • Numbness or weakness (nerve involvement)
  • Severe abdominal pain
What is livedo reticularis?
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It is a net-like purple discoloration of the skin, commonly seen in PAN and other vascular diseases.
How is PAN diagnosed?
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Diagnosis includes:

  • Blood tests (inflammation markers)
  • Hepatitis B testing
  • CT/MR angiography (to detect aneurysms)
  • Biopsy (skin, nerve, or muscle)
Is PAN curable?
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PAN is not completely curable, but it is treatable and controllable with proper therapy.
What is the treatment of PAN?
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Treatment depends on severity:

  • Glucocorticoids
  • Immunosuppressants (Methotrexate, Azathioprine)
  • Cyclophosphamide (severe cases)
  • Antiviral therapy (if Hepatitis B associated)
Can PAN be life-threatening?
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Yes, especially if major organs like the kidneys, gut, or heart are involved. Early diagnosis significantly improves outcomes.
Can PAN relapse?
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Yes, PAN can relapse, so regular follow-up is essential.
When should I see a rheumatologist?
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You should consult early if you have:

  • Unexplained fever + weight loss
  • Skin rash with pain
  • Numbness or weakness
  • Severe abdominal pain

Protect Your Blood Vessels

Early diagnosis supports healthier blood vessels and better long-term wellness outcomes.

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